β-Carotene and Other Carotenoids (2024)

  • Albanes D, Heinonen OP, Taylor PR, Virtamo J, Edwards BK, Rautalahti M, Hartman AM, Palmgren J, Freedman LS, Haapakoski J, Barrett MJ, Pietinen P, Malila N, Tala E, Liippo K, Salomaa ER, Tangrea JA, Teppo L, Askin FB, Taskinen E, Erozan Y, Greenwald P, Huttunen JK. 1996. α-Tocopherol and β-carotene supplements and lung cancer incidence in the Alpha-Tocopherol Beta-Carotene Prevention Study: Effects of base-line characteristics and study compliance. J Natl Cancer Inst 88:1560–1570. [PubMed: 8901854]

  • Albanes D, Virtamo J, Taylor PR, Rautalahti M, Pietinen P, Heinonen OP. 1997. Effects of supplemental beta-carotene, cigarette smoking, and alcohol co sumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am J Clin Nutr 66:366–372. [PubMed: 9250116]

  • Allard JP, Royall D, Kurian R, Muggli R, Jeejeebhoy KN. 1994. Effects of beta carotene supplementation on lipid peroxidation in humans. Am J Clin Nutr 59:884–890. [PubMed: 8147334]

  • ATBC (Alpha-Tocopherol, Beta Carotene) Cancer Prevention Study Group. 1994. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330:1029–1035. [PubMed: 8127329]

  • Baker DL, Krol ES, Jacobsen N, Liebler DC. 1999. Reactions of beta-carotene with cigarette smoke oxidants. Identification of carotenoid oxidation products and evaluation of the prooxidant/antioxidant effect. Chem Res Toxicol 12:535–543. [PubMed: 10368317]

  • Batieha AM, Armenian HK, Norkus EP, Morris JS, Spate VE, Comstock GW. 1993. Serum micronutrients and the subsequent risk of cervical cancer in a popul tion-based nested case-control study. Cancer Epidemiol Biomarkers Prev 2:335–339. [PubMed: 8348056]

  • Bendich A. 1988. The safety of beta-carotene. Nutr Cancer 11:207–214. [PubMed: 3064048]

  • Block G, Patterson B, Subar A. 1992. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence. Nutr Cancer 18:1–29. [PubMed: 1408943]

  • Blot WJ, Li J-Y, Taylor PR, Guo W, Dawsey S, Wang G-Q, Yang CS, Zheng S-F, Gail M, Li G-Y, Yu Y, Liu B-Q, Tangrea J, Sun Y-H, Liu F, Fraumeni JF Jr, Zhang Y-H, Li B. 1993. Nutrition intervention trials in Linxian, China: Supplement tion with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 85:1483–1492. [PubMed: 8360931]

  • Blot WJ, Li J-Y, Taylor PR, Li B. 1994. Lung cancer and vitamin supplementation. N Engl J Med 331:614. [PubMed: 8047094]

  • Boileau TW, Moore AC, Erdman JW Jr. 1999. Carotenoids and vitamin A. In: Papas AM, editor. , ed. Antioxidant Status, Diet, Nutrition, and Health.Boca Raton, FL: CRC Press. Pp.133–158.

  • Bone RA, Landrum JT, Tarsis SL. 1985. Preliminary identification of the human macular pigment. Vision Res 25:1531–1535. [PubMed: 3832576]

  • Bone RA, Landrum JT, Hime GW, Cains A, Zamor J. 1993. Stereochemistry of the human macular carotenoids. Invest Ophthalmol Vis Sci 34:2033–2040. [PubMed: 8491553]

  • Bonithon-Kopp C, Coudray C, Berr C, Touboul P-J, Feve JM, Favier A, Ducimetiere P. 1997. Combined effects of lipid peroxidation and antioxidant status on carotid atherosclerosis in a population aged 59–71 y: The EVA Study. Am J Clin Nutr 65:121–127. [PubMed: 8988923]

  • Brady WE, Mares-Perlman JA, Bowen P, Stacewicz-Sapuntzakis M. 1996. Human serum carotenoid concentrations are related to physiologic and lifestyle factors. J Nutr 126:129–137. [PubMed: 8558292]

  • Brown L, Rimm EB, Seddon JM, Giovannucci EL, Chasan-Taber L, Spiegelman D, Willett WC, Hankinson SE. 1999. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 70:517–524. [PubMed: 10500021]

  • Burri BJ, Dixon ZR, Fong AK, Kretsch MJ, Clifford AJ, Erdman JW Jr. 1993. Possible association of skin lesions with a low-carotene diet in premenopausal women. Ann NY Acad Sci 691:279–280. [PubMed: 8129312]

  • Butte NF, Calloway DH. 1981. Evaluation of lactational performance of Navajo women. Am J Clin Nutr 34:2210–2215. [PubMed: 7293949]

  • Calzada C, Bizzotto M, Paganga G, Miller NJ, Bruckdorfer KR, Diplock AT, Rice-Evans CA. 1995. Levels of antioxidant nutrients in plasma and low density lipoproteins: A human volunteer supplementation study. Free Radic Res 23:489–503. [PubMed: 7581831]

  • Canfield LM, Giuliano AR, Neilson EM, Yap HH, Graver EJ, Cui HA, Blashill BM. 1997. Beta-carotene in breast milk and serum is increased after a single beta carotene dose. Am J Clin Nutr 66:52–61. [PubMed: 9209169]

  • Canfield LM, Giuliano AR, Neilson EM, Blashil BM, Graver EJ, Yap HH. 1998. Kinetics of the response of milk and serum beta-carotene to daily beta-car tene supplementation in healthy, lactating women. Am J Clin Nutr 67:276–283. [PubMed: 9459376]

  • Castenmiller JJ, West CE. 1998. Bioavailability and bioconversion of carotenoids. Annu Rev Nutr 18:19–38. [PubMed: 9706217]

  • Chandler LA, Schwartz SJ. 1987. HPLC separation of cis-trans carotene isomers in fresh and processed fruits and vegetables. J Food Sci 52:669–672.

  • Chappell JE, Francis T, Clandinin MT. 1985. Vitamin A and E content of human milk at early stages of lactation. Early Hum Devel 11:157–167. [PubMed: 4029052]

  • Chasan-Taber L, Willett WC, Seddon JM, Stampfer M, Rosner B, Colditz GA, Speizer FE, Hankinson SE. 1999. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 70:509–516. [PubMed: 10500020]

  • Chow CK, Thacker RR, Changchit C, Bridges RB, Rehm SR, Humble J, Turbek J. 1986. Lower levels of vitamin C and carotenes in plasma of cigarette smokers. J Am Coll Nutr 5:305–312. [PubMed: 3734276]

  • Chug-Ahuja JK, Holden JM, Forman MR, Mangels AR, Beecher GR, Lanza E. 1993. The development and application of a carotenoid database for fruits, veget bles, and selected multicomponent foods. J Am Diet Assoc 93:318–323. [PubMed: 8440830]

  • Clevidence BA, Khachik F, Brown ED, Nair PP, Wiley ER, Prior RL, Cao G, Morel DW, Stone W, Gross M, Kramer TR. 1997. Human consumption of carotenoid rich vegetables. In: Aruoma OI, editor; , Cuppett SL, editor. , eds. Antioxidant Methodology: In Vivo and In Vitro Concepts.Champaign, IL: AOCS Press. Pp53–63.

  • Clinton SK. 1998. Lycopene: Chemistry, biology, and implications for human health and disease. Nutr Rev 56:35–51. [PubMed: 9529899]

  • Clinton SK, Emenhiser C, Schwartz S, Bostwick DG, Williams AW, Moore BJ, Erdman JW Jr. 1996. Cis-trans lycopene isomers, carotenoids, and retinol in the human prostate. Cancer Epidemiol Biomarkers Prev 5:823–833. [PubMed: 8896894]

  • Comstock GW, Menkes MS, Schober SE, Vuilleumier J-P, Helsing KJ. 1988. Serum levels of retinol, beta-carotene, and alpha-tocopherol in older adults. Am J Epidemiol 127:114–123. [PubMed: 3276153]

  • Connett JE, Kuller LH, Kjelsberg MO, Polk BF, Collins G, Rider A, Hulley SB. 1989. Relationship between carotenoids and cancer. The Multiple Risk Factor Intervention Trial (MRFIT) Study. Cancer 64:126–134. [PubMed: 2731108]

  • Coodley GO, Nelson HD, Loveless MO, Folk C. 1993. Beta-carotene in HIV infection. J Acquir Immune Defic Syndr 6:272–276. [PubMed: 8450402]

  • de Pee S, West CE, Muhilal, Karyadi D, Hautvast J. 1995. Lack of improvement in vitamin A status with increased consumption of dark-green leafy vegetables. Lancet 346:75–81. [PubMed: 7603216]

  • de Pee S, West CE, Permaesih D, Martuti S, Muhilal, Hautvast J. 1998. Orange fruit is more effective than are dark-green, leafy vegetables in increasing serum concentrations of retinol and beta-carotene in schoolchildren in Indonesia. Am J Clin Nutr 68:1058–1067. [PubMed: 9808223]

  • Dietz JM, Kantha SS, Erdman JW Jr. 1988. Reversed phase HPLC analysis of alpha and beta-carotene from selected raw and cooked vegetables. Plant Food Hum Nutr 38:333–341. [PubMed: 3237635]

  • Dixon ZR, Burri BJ, Clifford A, Frankel EN, Schneeman BO, Parks E, Keim NL, Barbieri T, Wu M-M, Fong AK, Kretsch MJ, Sowell AL, Erdman JW Jr. 1994. Effects of a carotene-deficient diet on measures of oxidative susceptibility and superoxide dismutase activity in adult women. Free Radic Biol Med 17:537–544. [PubMed: 7867970]

  • Dixon ZR, Shie F-S, Warden BA, Burri BJ, Neidlinger TR. 1998. The effect of a low carotenoid diet on malondialdehyde-thiobarbituric acid (MDA-TBA) concentrations in women: A placebo-controlled double-blind study. J Am Coll Nutr 17:54–58. [PubMed: 9477390]

  • EDCCSG (Eye Disease Case-Control Study Group). 1993. Antioxidant status and neovascular age-related macular degeneration. Arch Ophthalmol 111:104–109. [PubMed: 7678730]

  • Eichholzer M, Stahelin HB, Gey KF. 1992. Inverse correlation between essential antioxidants in plasma and subsequent risk to develop cancer, ischemic heart disease and stroke respectively: 12-year follow-up of the Prospective Basel Study. Exp Suppl 62:398–410. [PubMed: 1450600]

  • Elinder LS, Hadell K, Johansson J, Molgaard J, Holme I, Olsson AG, Walldius G. 1995. Probucol treatment decreases serum concentrations of diet-derived ant oxidants. Arterioscler Thromb Vasc Biol 15:1057–1063. [PubMed: 7627696]

  • Erdman JW Jr, Bierer TL, Gugger ET. 1993. Absorption and transport of car tenoids. Ann NY Acad Sci 691:76–85. [PubMed: 8129321]

  • Fukao A, Tsubono Y, Kawamura M, Ido T, Akazawa N, Tsuji I, Komatsu S, Minami Y, Hisamichi S. 1996. The independent association of smoking and drinking with serum beta-carotene levels among males in Miyagi, Japan. Int J Epidemiol 25:300–306. [PubMed: 9119555]

  • Gartner C, Stahl W, Sies H. 1997. Lycopene is more bioavailable from tomato paste than from fresh tomatoes. Am J Clin Nutr 66:116–122. [PubMed: 9209178]

  • Gaziano JM, Hennekens CH. 1993. The role of beta-carotene in the prevention of cardiovascular disease. Ann NY Acad Sci 691:148–155. [PubMed: 8129284]

  • Gaziano JM, Hatta A, Flynn M, Johnson EJ, Krinsky NI, Ridker PM, Hennekens CH, Frei B. 1995. Supplementation with beta-carotene in vivo and in vitro does not inhibit low density lipoprotein oxidation. Atherosclerosis 112:187–195. [PubMed: 7772078]

  • Gebre-Medhin M, Vahlquist A, Hofvander Y, Uppsall L, Vahlquist B. 1976. Breast milk composition in Ethiopian and Swedish mothers. I. Vitamin A and beta-carotene. Am J Clin Nutr 29:441–451. [PubMed: 944526]

  • Gey KF, Moser UK, Jordan P, Stahelin HB, Eichholzer M, Ludin E. 1993. a. Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: An epidemiological update with special attention to carotene and vitamin C. Am J Clin Nutr 57:787S–797S. [PubMed: 8475897]

  • Gey KF, Stähelin HB, Eichholzer M. 1993. b. Poor plasma status of carotene and vitamin C is associated with higher morbidity from ischemic heart disease and stroke: Basel Prospective Study. Clin Invest 71:3–6. [PubMed: 8453256]

  • Giovannucci E. 1999. Tomatoes, tomato-based products, lycopene, and cancer: Review of the epidemiologic literature. J Natl Cancer Inst 91:317–331. [PubMed: 10050865]

  • Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. 1995. Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst 87:1767–1776. [PubMed: 7473833]

  • Giuliano AR, Neilson EM, Kelly BE, Canfield LM. 1992. Simultaneous quantitation and separation of carotenoids and retinol in human milk by high-performance liquid chromatography. Methods Enzymol 213:391–399. [PubMed: 1435312]

  • Giuliano AR, Neilson SM, Yap H-H, Baier M, Canfield LM. 1994. Quantitation of and inter/intra-individual variability in major carotenoids of mature human milk. J Nutr Biochem 5:551–556.

  • Goodman DS, Blomstrand R, Werner B, Huang HS, Shiratori T. 1966. The intestinal absorption and metabolism of vitamin A and beta-carotene in man. J Clin Invest 45:1615–1623. [PMC free article: PMC292843] [PubMed: 5925518]

  • Gottlieb K, Zarling EJ, Mobarhan S, Bowen P, Sugerman S. 1993. Beta-carotene decreases markers of lipid peroxidation in healthy volunteers. Nutr Cancer 19:207–212. [PubMed: 8502591]

  • Greenberg ER, Baron JA, Karagas MR, Stukel TA, Nierenberg DW, Stevens MM, Mandel JS, Haile RW. 1996. Mortality associated with low plasma concentr tion of beta carotene and the effect of oral supplementation. J Am Med Assoc 275:699–703. [PubMed: 8594267]

  • Hammond BR Jr, Fuld K. 1992. Interocular differences in macular pigment density. Invest Ophthalmol Vis Sci 33:350–355. [PubMed: 1740365]

  • Hammond BR Jr, Curran-Celentano J, Judd S, Fuld K, Krinsky NI, Wooten BR, Snodderly DM. 1996. Sex differences in macular pigment optical density: R lation to plasma carotenoid concentrations and dietary patterns. Vision Res 36:2001–2012. [PubMed: 8759440]

  • Hammond BR Jr, Johnson EJ, Russell RM, Krinsky NI, Yeum K-J, Edwards RB, Snodderly DM. 1997. Dietary modification of human macular pigment density. Invest Ophthalmol Vis Sci 38:1795–1801. [PubMed: 9286268]

  • Handelman GJ, Dratz EA, Reay CC, Van Kuijk JG. 1988. Carotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci 29:850–855. [PubMed: 3372162]

  • Handelman GJ, Packer L, Cross CE. 1996. Destruction of tocopherols, carotenoids, and retinol in human plasma by cigarette smoke. Am J Clin Nutr 63:559–565. [PubMed: 8599320]

  • Hanusch M, Stahl W, Schulz WA, Sies H. 1995. Induction of gap junctional co munication by 4-oxoretinoic acid generated from its precursor canthaxanthin. Arch Biochem Biophys 317:423–428. [PubMed: 7893159]

  • Health Canada. 1997. Canada's Food Guide to Healthy Eating. Minister of Public Works and Government Services Canada.

  • Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, Belanger C, LaMotte F, Gaziano JM, Ridker PM, Willett W, Peto R. 1996. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 334:1145–1149. [PubMed: 8602179]

  • Herbeth B, Didelot-Barthelemy L, Lemoine A, Le Devehat C. 1988. Plasma fat soluble vitamins and alcohol consumption. Am J Clin Nutr 47:343–344. [PubMed: 3341269]

  • Herbeth B, Chavance M, Musse N, Mejean L, Vernhes G. 1990. Determinants of plasma retinol, beta-carotene, and alpha-tocopherol. Am J Epidemiol 132:394–396. [PubMed: 2372016]

  • Heywood R, Palmer AK, Gregson RL, Hummler H. 1985. The toxicity of beta-carotene. Toxicology 36:91–100. [PubMed: 4049434]

  • Hininger I, Chopra M, Thurnham DI, Laporte F, Richard M-J, Favier A, Roussel A-M. 1997. Effect of increased fruit and vegetable intake on the susceptibility of lipoprotein to oxidation in smokers. Eur J Clin Nutr 51:601–606. [PubMed: 9306086]

  • Holden JM, Eldridge AL, Beecher GR, Buzzard M, Bhagwat S, Davis CS, Douglass LW, Gebhardt S, Haytowitz D, Schakel S. 1999. Carotenoid content of U.S. foods: an update of the database. Food Comp Anal 12:169–196.

  • Hollander D, Ruble RE. 1978. Beta-carotene intestinal absorption: bile, fatty acid, pH, and flow rate effects on transport. Am J Physiology. 235:e686–e691. [PubMed: 32773]

  • Hughes DA, Wright AJ, Finglas PM, Peerless AC, Bailey AL, Astley SB, Pinder AC, Southon S. 1997. The effect of beta-carotene supplementation on the i mune function of blood monocytes from healthy male nonsmokers. J Lab Clin Med 129:309–317. [PubMed: 9042816]

  • Jacques PF, Chylack LT Jr. 1991. Epidemiologic evidence of a role for the antiox dant vitamins and carotenoids in cataract prevention. Am J Clin Nutr 53:352S–355S. [PubMed: 1985409]

  • Jalal F, Nesheim MC, Agus Z, Sanjur D, Habicht JP. 1998. Serum retinol concentr tions in children are affected by food sources of beta-carotene, fat intake, and anthelmintic drug treatment. Am J Clin Nutr 68:623–629. [PubMed: 9734739]

  • Johnson EJ, Russell RM. 1992. Distribution of orally administered beta-carotene among lipoproteins in healthy men. Am J Clin Nutr 56:128–135. [PubMed: 1609749]

  • Johnson EJ, Qin J, Krinsky NI, Russell RM. 1997. Beta-carotene isomers in human serum, breast milk and buccal mucosa cells after continuous oral doses of all-trans and 9-cis beta-carotene. J Nutr 127:1993–1999. [PubMed: 9311956]

  • Kaplan LA, Lau JM, Stein EA. 1990. Carotenoid composition, concentrations, and relationships in various human organs. Clin Physiol Biochem 8:1–10. [PubMed: 2323157]

  • Khachik F, Bernstein PS, Garland DL. 1997. a. Identification of lutein and zeaxa thin oxidation products in human and monkey retinas. Invest Ophthalmol Vis Sci 38:1802–1811. [PubMed: 9286269]

  • Khachik F, Spangler CJ, Smith JC, Canfield LM, Steck A, Pfander H. 1997. b. Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum. Anal Chem 69:1873–1881. [PubMed: 9164160]

  • Kobza A, Ramsay CA, Magnus IA. 1973. Oral carotene therapy in actinic reticuloid and solar urticaria. Failure to demonstrate a photoprotective effect against long wave ultraviolet and visible radiation. Br J Dermatol 88:157–166. [PubMed: 4574773]

  • Kohlmeier L, Hastings SB. 1995. Epidemiologic evidence of a role of carotenoids in cardiovascular disease prevention. Am J Clin Nutr 62:1370S–1376S. [PubMed: 7495233]

  • Kohlmeier L, Kark JD, Gomez-Gracia E, Martin BC, Steck SE, Kardinaal AF, Ringstad J, Thamm M, Masaev V, Riemersma R, Martin-Moreno JM, Huttunen JK, Kok FJ. 1997. Lycopene and myocardial infarction risk in the EURAMIC Study. Am J Epidemiol 146:618–626. [PubMed: 9345115]

  • Koonsvitsky BP, Berry DA, Jones MB, Lin PY, Cooper DA, Jones DY, Jackson JE. 1997. Olestra affects serum concentrations of alpha-tocopherol and car tenoids but not vitamin D or vitamin K status in free-living subjects. J Nutr 127:1636S–1645S. [PubMed: 9237960]

  • Kostic D, White WS, Olson JA. 1995. Intestinal absorption, serum clearance, and interactions between lutein and beta-carotene when administered to human adults in separate or combined oral doses. Am J Clin Nutr 62:604–610. [PubMed: 7661123]

  • Kramer TR, Burri BJ. 1997. Modulated mitogenic proliferative responsiveness of lymphocytes in whole-blood cultures after a low-carotene diet and mixed-carotenoid supplementation in women. Am J Clin Nutr 65:871–875. [PubMed: 9062542]

  • Krinsky NI. 1993. Actions of carotenoids in biological systems. Annu Rev Nutr 13:561–587. [PubMed: 8369159]

  • Kuhnlein HV, Soueida R, Receveur O. 1996. Dietary nutrient profiles of Canadian Baffin Island Inuit differ by food source, season, and age. J Am Diet Assoc 96:155–162. [PubMed: 8557942]

  • Kushi LH, Folsom AR, Prineas RJ, Mink PJ, Wu Y, Bostick RM. 1996. Dietary antio idant vitamins and death from coronary heart disease in postmenopausal women. N Engl J Med 334:1156–1162. [PubMed: 8602181]

  • Lachance PA. 1997. Nutrient addition to foods: The public health impact in cou tries with rapidly westernizing diets. In: Bendich A, editor; , Deckelbaum RJ, editor. , eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals.Totowa, NJ: Humana Press. Pp.441–454.

  • Lascari AD. 1981. Carotenemia. A review. Clin Pediatr 20:25–29. [PubMed: 7449242]

  • Le Marchand L, Hankin JH, Kolonel LN, Beecher GR, Wilkens LR, Zhao LP. 1993. Intake of specific carotenoids and lung cancer risk. Cancer Epidemiol Biomarkers Prev 2:183–187. [PubMed: 8318869]

  • Lewis MB. 1972. The effect of beta-carotene on serum vitamin A levels in erythr poietic protoporphyria. Australas J Dermatol 13:75–78. [PubMed: 4644766]

  • Lin Y, Burri BJ, Neidlinger TR, Muller HG, Dueker SR, Clifford A. 1998. Estimating the concentration of beta-carotene required for maximal protection of low-density lipoproteins in women. Am J Clin Nutr 67:837–845. [PubMed: 9583839]

  • LSRO/FASEB (Life Sciences Research Office/Federation of American Societies for Experimental Biology). 1995. Third Report on Nutrition Monitoring in theUnited States.Washington, DC: US Government Printing Office.

  • Mahapatra S, Manorama R. 1997. The protective effect of red palm oil in compa ison with massive vitamin A dose in combating vitamin A deficiency in Orissa, India. Asia Pacific J Clin Nutr 6:246–250. [PubMed: 24394783]

  • Mangels AR, Holden JM, Beecher GR, Forman MR, Lanza E. 1993. Carotenoid content of fruits and vegetables: An evaluation of analytic data. J Am Diet Assoc 93: 284–296. [PubMed: 8440826]

  • Manson JE, Gaziano JM, Jonas MA, Hennekens CH. 1993. Antioxidants and cardi vascular disease: A review. J Am Coll Nutr 12:426–432. [PubMed: 8409105]

  • Mares-Perlman JA, Brady WE, Klein R, Klein BE, Palta M, Bowen P, Stacewicz-Sapuntzakis M. 1994. Serum levels of carotenoids and tocopherols in people with age-related maculopathy. Invest Ophthalmol Vis Sci 35:2004.

  • Mares-Perlman JA, Brady WE, Klein BE, Klein R, Palta M, Bowen P, Stacewicz-Sapuntzakis M. 1995. Serum carotenoids and tocopherols and severity of n clear and cortical opacities. Invest Ophthalmol Vis Sci 36:276–288. [PubMed: 7843899]

  • Margetts BM, Jackson AA. 1996. The determinants of plasma beta-carotene: Inte action between smoking and other lifestyle factors. Eur J Clin Nutr 50:236–238. [PubMed: 8730610]

  • Martini MC, Campbell DR, Gross MD, Grandits GA, Potter JD, Slavin JL. 1995. Plasma carotenoids as biomarkers of vegetable intake: The University of Mi nesota Cancer Prevention Research Unit Feeding Studies. Cancer Epidemiol Biomarkers Prev 4:491–496. [PubMed: 7549804]

  • Mathews-Roth MM. 1986. Beta-carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases. Biochimie 68:875–884. [PubMed: 3092881]

  • Mathews-Roth MM, Pathak MA, Parrish J, Fitzpatrick TB, Kass EH, Toda K, Clemens W. 1972. A clinical trial of the effects of oral beta-carotene on the respon es of human skin to solar radiation. J Invest Dermatol 59:349–353. [PubMed: 4569104]

  • Mathews-Roth MM, Pathak MA, Fitzpatrick TB, Harber LC, Kass EH. 1974. Beta-carotene as an oral photoprotective agent in erythropoietic protoporphyria. J Am Med Assoc 228:1004–1008. [PubMed: 4406335]

  • Mayne ST. 1996. Beta-carotene, carotenoids, and disease prevention in humans. FASEB J 10:690–701. [PubMed: 8635686]

  • Mayne ST. 1998. Beta-carotene, Carotenoids and Cancer Prevention. In: DeVita VT Jr, editor; , Hellman S, editor; , Rosenberg SA, editor. , eds. Principles and Practice of Oncology (PPO), 5th Edition Updates. Philadelphia, PA: Lippincott-Raven Publishers. Pp. 12:1–15.

  • Mayne ST, Goodwin WJ Jr. 1993. Chemoprevention of head and neck cancer. Current Opinion Otolaryn Head Neck Surg 1:126–132.

  • Mayne ST, Cartmel B, Silva F, Kim CS, Fallon BG, Briskin K, Zheng T, Baum M, Shor-Posner G, Goodwin WJ Jr. 1998. Effect of supplemental beta-carotene on plasma concentrations of carotenoids, retinol, and alpha-tocopherol in humans. Am J Clin Nutr 68:642–647. [PubMed: 9734742]

  • Menkes MS, Comstock GW, Vuilleumier JP, Helsing KJ, Rider AA, Brookmeyer R. 1986. Serum beta-carotene, vitamins A and E, selenium, and the risk of lung cancer. N Engl J Med 315:1250–1254. [PubMed: 3773937]

  • Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, Beecher GR, Smith JC. 1992. Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men. Am J Clin Nutr 55:1120–1125. [PubMed: 1595584]

  • Mobarhan S, Bowen P, Andersen B, Evans M, Stacewicz-Sapuntzakis M, Sugerman S, Simms P, Lucchesi D, Friedman H. 1990. Effects of beta-carotene repletion on beta-carotene absorption, lipid peroxidation, and neutrophil superoxide formation in young men. Nutr Cancer 14:195–206. [PubMed: 1964728]

  • Morris DL, Kritchevsky SB, Davis CE. 1994. Serum carotenoids and coronary heart disease: The Lipid Research Clinics Coronary Primary Prevention Trial and Follow-up Study. J Am Med Assoc 272:1439–1441. [PubMed: 7933426]

  • Mosca L, Rubenfire M, Mandel C, Rock C, Tarshis T, Tsai A, Pearson T. 1997. Antioxidant nutrient supplementation reduces the susceptibility of low dens ty lipoprotein to oxidation in patients with coronary artery disease. J Am Coll Cardiol 30:392–399. [PubMed: 9247510]

  • Nebeling LC, Forman MR, Graubard BI, Snyder RA. 1997. Changes in carotenoid intake in the United States: The 1987 and 1992 National Health Interview Surveys. J Am Diet Assoc 97:991–996. [PubMed: 9284877]

  • Nierenberg DW, Dain BJ, Mott LA, Baron JA, Greenberg ER. 1997. Effects of 4 y of oral supplementation with beta-carotene on serum concentrations of retinol, tocopherol, and five carotenoids. Am J Clin Nutr 66:315–319. [PubMed: 9250109]

  • Nomura AM, Stemmermann GN, Heilbrun LK, Salkeld RM, Vuilleumier JP. 1985. Serum vitamin levels and the risk of cancer of specific sites in men of Japanese ancestry in Hawaii. Cancer Res 45:2369–2372. [PubMed: 3986777]

  • Nomura AM, Stemmermann GN, Lee J, Craft NE. 1997. Serum micronutrients and prostate cancer in Japanese Americans in Hawaii. Cancer Epidemiol Biomarkers Prev 6:487–491. [PubMed: 9232334]

  • Olson JA. 1989. Biological actions of carotenoids. J Nutr 119:94–95. [PubMed: 2913240]

  • Olson JA. 1994. Absorption, transport, and metabolism of carotenoids in humans. Pure Appl Chem 66:1011–1016.

  • Olson JA. 1999. Carotenoids. In: Shils ME, editor; , Olson JA, editor; , Shike M, editor; , Ross AC, editor. , eds. Modern Nutrition in Health and Disease,9th edition. Baltimore, MD: Williams & Wilkins. Pp.525–541.

  • Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL Jr, Valanis B, Williams JH Jr, Barnhart S, Cherniack MG, Brodkin CA, Hammar S. 1996. a. Risk factors for lung cancer and for interve tion effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J Natl Cancer Inst 88:1550–1559. [PubMed: 8901853]

  • Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL Jr, Valanis B, Williams JH Jr, Barnhart S, Hammar S. 1996. b. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334:1150–1155. [PubMed: 8602180]

  • Ostrea EM Jr, Balun JE, Winkler R, Porter T. 1986. Influence of breast-feeding on the restoration of the low serum concentration of vitamin E and beta-carotene in the newborn infant. Am J Obstet Gynecol 154:1014–1017. [PubMed: 3706423]

  • Pamuk ER, Byers T, Coates RJ, Vann JW, Sowell AL, Gunter EW, Glass D. 1994. Effect of smoking on serum nutrient concentrations in African-American women. Am J Clin Nutr 59:891–895. [PubMed: 8147335]

  • Pandey DK, Shekelle R, Selwyn BJ, Tangney C, Stamler J. 1995. Dietary vitamin C and beta-carotene and risk of death in middle-aged men. The Western Electric Study. Am J Epidemiol 142:1269–1278. [PubMed: 7503047]

  • Parker RS. 1988. Carotenoid and tocopherol composition of human adipose tissue. Am J Clin Nutr 47:33–36. [PubMed: 3337039]

  • Parker RS. 1996. Absorption, metabolism, and transport of carotenoids. FASEB J 10:542–551. [PubMed: 8621054]

  • Patton S, Canfield LM, Huston GE, Ferris AM, Jensen RG. 1990. Carotenoids of human colostrum. Lipids 25:159–165. [PubMed: 2333016]

  • Pool-Zobel BL, Bub A, Muller H, Wollowski I, Rechkemmer G. 1997. Consumption of vegetables reduces genetic damage in humans: First results of a human intervention trial with carotenoid-rich foods. Carcinogenesis 18:1847–1850. [PubMed: 9328185]

  • Richards GA, Theron AJ, Van Rensburg CE, Van Rensburg AJ, Van der Merwe CA, Kuyl JM, Anderson R. 1990. Investigation of the effects of oral administration of vitamin E and beta-carotene on the chemiluminescence responses and the frequency of sister chromatid exchanges in circulating leukocytes from cigarette smokers. Am Rev Respir Dis 142:648–654. [PubMed: 2167623]

  • Riemersma RA, Wood DA, Macintyre CC, Elton RA, Gey KF, Oliver MF. 1991. Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene. Lancet 337:1–5. [PubMed: 1670647]

  • Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. 1993. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 328:1450–1456. [PubMed: 8479464]

  • Rock CL, Swendseid ME. 1992. Plasma beta-carotene response in humans after meals supplemented with dietary pectin. Am J Clin Nutr 55:96–99. [PubMed: 1309477]

  • Rodriguez MS, Irwin MI. 1972. A conspectus of research on vitamin A requir ments of man. J Nutr 102:909–968. [PubMed: 4556123]

  • Roels OA, Trout M, Dujacquier R. 1958. Carotene balances on boys in Ruanda where vitamin A deficiency is prevalent. J Nutr 65:115–127. [PubMed: 13550006]

  • Rust P, Eichler I, Renner S, Elmadfa I. 1998. Effects of long-term oral beta-car tene supplementation on lipid peroxidation in patients with cystic fibrosis. Int J Vitam Nutr Res 68:83–87. [PubMed: 9565821]

  • Sahyoun NR, Jacques PF, Russell RM. 1996. Carotenoids, vitamins C and E, and mortality in an elderly population. Am J Epidemiol 144:501–511. [PubMed: 8781466]

  • Salgo MG, Cueto R, Winston GW, Pryor WA. 1999. Beta carotene and its oxidation products have different effects on microsome mediated binding of benzo[a]pyrene to DNA. Free Radic Biol Med 26:162–173. [PubMed: 9890651]

  • Salonen JT, Nyyssonen K, Parviainen M, Kantola M, Korpela H, Salonen R. 1993. Low plasma beta-carotene, vitamin E and selenium levels associate with acce erated carotid atherogenesis in hypercholesterolemic eastern Finnish men. Circulation 87:678.

  • Santos MS, Meydani SN, Leka L, Wu D, Fotouhi N, Meydani M, Hennekens CH, Gaziano JM. 1996. Natural killer cell activity in elderly men is enhanced by beta-carotene supplementation. Am J Clin Nutr 64:772–777. [PubMed: 8901800]

  • Santos MS, Gaziano JM, Leka LS, Beharka AA, Hennekens CH, Meydani SN. 1998. Beta-carotene-induced enhancement of natural killer cell activity in elderly men: An investigation of the role of cytokines. Am J Clin Nutr 68:164–170. [PubMed: 9665110]

  • Schmitz HH, Poor CL, Wellman RB, Erdman JW Jr. 1991. Concentrations of selected carotenoids and vitamin A in human liver, kidney and lung tissue. J Nutr 121:1613–1621. [PubMed: 1765826]

  • Seddon JM, Ajani UA, Sperduto RD, Hiller R, Blair N, Burton TC, Farber MD, Gragoudas ES, Haller J, Miller DT, Yannuzzi LA, Willett W. 1994. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. J Am Med Assoc 272:1413–1420. [PubMed: 7933422]

  • Shoenfeld Y, Shaklai M, Ben-Baruch N, Hirschorn M, Pinkhaus J. 1982. Neutropenia induced by hypercarotenaemia. Lancet 1:1245. [PubMed: 6122999]

  • Sies H, Stahl W. 1997. Carotenoids and intercellular communication via gap junctions. Int J Vitam Nutr Res 67:364–367. [PubMed: 9350479]

  • Snodderly DM. 1995. Evidence for protection against age-related macular degene ation by carotenoids and antioxidant vitamins. Am J Clin Nutr 62:1448S–1461S. [PubMed: 7495246]

  • Stahelin HB, Gey KF, Eichholzer M, Ludin E, Bernasconi F, Thurneysen J, Brubacher G. 1991. Plasma antioxidant vitamins and subsequent cancer mortality in the 12-year follow-up of the Prospective Basel Study. Am J Epidemiol 133:766–775. [PubMed: 2021143]

  • Stahl W, Sies H. 1992. Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J Nutr 122:2161–2166. [PubMed: 1432255]

  • Stahl W, Schwarz W, Sundquist AR, Sies H. 1992. Cis-trans isomers of lycopene and beta-carotene in human serum and tissues. Arch Biochem Biophys 294:173–177. [PubMed: 1550343]

  • Steinberg FM, Chait A. 1998. Antioxidant vitamin supplementation and lipid pe oxidation in smokers. Am J Clin Nutr 68:319–327. [PubMed: 9701189]

  • Stryker WS, Kaplan LA, Stein EA, Stampfer MJ, Sober A, Willett WC. 1988. The relation of diet, cigarette smoking, and alcohol consumption to plasma beta-carotene and alpha-tocopherol levels. Am J Epidemiol 127:283–296. [PubMed: 3257350]

  • Taylor A. 1993. Cataract: Relationship between nutrition and oxidation. J Am Coll Nutr 12:138–146. [PubMed: 8463513]

  • Taylor A, Jacques PF, Epstein EM. 1995. Relations among aging, antioxidant status, and cataract. Am J Clin Nutr 62:1439S–1447S. [PubMed: 7495245]

  • Traber MG, Diamond SR, Lane JC, Brody RI, Kayden HJ. 1994. Beta-carotene transport in human lipoproteins. Comparisons with alpha-tocopherol. Lipids 29:665–669. [PubMed: 7861932]

  • VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, Stacewicz-Sapuntzakis M, Mares-Perlman JA. 1996. Influence of using diffe ent sources of carotenoid data in epidemiologic studies. J Am Diet Assoc 96:1271–1275. [PubMed: 8948389]

  • van het Hof KH, Brouwer IA, West CE, Haddeman E, Steegers-Theunissen RP, van Dusseldorp M, Weststrate JA, Eskes TK, Hautvast JG. 1999. Bioavailability of lutein from vegetables is 5 times higher than that of beta-carotene. Am J Clin Nutr 70:261–268. [PubMed: 10426704]

  • van Poppel G, Kok FJ, Duijzings P, de Vogel N. 1992. a. No influence of beta-car tene on smoking-induced DNA damage as reflected by sister chromatid exchanges. Int J Cancer 51:355–358. [PubMed: 1592526]

  • van Poppel G, Kok FJ, Hermus RJ. 1992. b. Beta-carotene supplementation in smo ers reduces the frequency of micronuclei in sputum. Br J Cancer 66:1164–1168. [PMC free article: PMC1978057] [PubMed: 1457358]

  • van Poppel G, Poulsen H, Loft S, Verhagen H. 1995. No influence of beta carotene on oxidative DNA damage in male smokers. J Natl Cancer Inst 87:310–311. [PubMed: 7707423]

  • van Vliet T, Schreurs WH, van Den Berg H. 1995. Intestinal beta-carotene absor tion and cleavage in men: Response of beta-carotene and retinyl esters in the triglyceride-rich lipoprotein fraction after a single oral dose of beta-carotene. Am J Clin Nutr 62:110–116. [PubMed: 7598052]

  • Wahlqvist ML, Wattanapenpaiboon N, Macrae FA, Lambert JR, MacLennan R, Hsu-Hage BH. 1994. Changes in serum carotenoids in subjects with colorectal adenomas after 24 mo of beta-carotene supplementation. Australian Polyp Prevention Project Investigators. Am J Clin Nutr 60:936–943. [PubMed: 7985637]

  • Wang X-D. 1994. Absorption and metabolism of beta-carotene. J Am Coll Nutr 13:314–325. [PubMed: 7963135]

  • Wang X-D, Liu C, Bronson RT, Smith DE, Krinsky NI, Russell RM. 1999. Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke. J Natl Cancer Inst 91:60–66. [PubMed: 9890171]

  • Wang Y, Ichiba M, Oishi H, Iyadomi M, Shono N, Tomokuni K. 1997. Relationship between plasma concentrations of beta-carotene and alpha-tocopherol and life-style factors and levels of DNA adducts in lymphocytes. Nutr Cancer 27:69–73. [PubMed: 8970185]

  • West S, Vitale S, Hallfrisch J, Munoz B, Muller D, Bressler S, Bressler NM. 1994. Are antioxidants or supplements protective for age-related macular degeneration?Arch Ophthalmol 112:222–227. [PubMed: 8311777]

  • Weststrate JA, Meijer GW. 1998. Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 52:334–343. [PubMed: 9630383]

  • Weststrate JA, van her Hof KH. 1995. Sucrose polyester and plasma carotenoid concentrations in healthy subjects. Am J Clin Nutr 62:591–597. [PubMed: 7661121]

  • White WS, Stacewicz-Sapuntzakis M, Erdman JW Jr, Bowen PE. 1994. Pharmacok netics of beta-carotene and canthaxanthin after ingestion of individual and combined doses by human subjects. J Am Coll Nutr 13:665–671. [PubMed: 7706602]

  • Winklhofer-Roob BM, Puhl H, Khoschsorur G, van't Hof MA, Esterbauer H, Shmerling DH. 1995. Enhanced resistance to oxidation of low density lipopr teins and decreased lipid peroxide formation during beta-carotene supplementation in cystic fibrosis. Free Radic Biol Med 18:849–859. [PubMed: 7797092]

  • Witter FR, Blake DA, Baumgardner R, Mellits ED, Niebyl JR. 1982. Folate, carotene, and smoking. Am J Obstet Gynecol 144:857. [PubMed: 7148912]

  • WCRF/AICR (World Cancer Research Fund/American Institute for Cancer Research). 1997. Food, Nutrition and the Prevention of Cancer: A Global Perspective.Menasha, WI: BANTA Book Group.

  • Yong LC, Forman MR, Beecher GR, Graubard BI, Campbell WS, Reichman ME, Taylor PR, Lanza E, Holden JM, Judd JT. 1994. Relationship between dietary intake and plasma concentrations of carotenoids in premenopausal women: Application of the USDA-NCI carotenoid food-composition database. Am J Clin Nutr 60:223–230. [PubMed: 8030600]

  • Zhang L-X, Cooney RV, Bertram JS. 1991. Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: Relationship to their cancer chemopreventive action. Carcinogenesis 12:2109–2114. [PubMed: 1934296]

  • Zheng W, Blot WJ, Diamond EL, Norkus EP, Spate V, Morris JS, Comstock GW. 1993. Serum micronutrients and the subsequent risk of oral and pharyngeal cancer. Cancer Res 53:795–798. [PubMed: 8428360]

  • Ziegler RG, Colavito EA, Hartge P, McAdams MJ, Schoenberg JB, Mason TJ, Fraumeni JF Jr. 1996. a. Importance of alpha-carotene, beta-carotene, and other phytochemicals in the etiology of lung cancer. J Natl Cancer Inst 88:612–615. [PubMed: 8609663]

  • Ziegler RG, Mayne ST, Swanson CA. 1996. b. Nutrition and lung cancer. Cancer Causes Control 7:157–177. [PubMed: 8850443]

  • Zino S, Skeaff M, Williams S, Mann J. 1997. Randomised controlled trial of effect of fruit and vegetable consumption on plasma concentrations of lipids and antioxidants. Br Med J 314:1787–1791. [PMC free article: PMC2126938] [PubMed: 9224079]

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